Mucosal Immunization

Arginine-glysine-aspartate motif enhances immunogenicity of antigens

Published in Vaccine Weekly, February 18th, 2004

The arginine-glysine-aspartate (RGD) motif enhances immunogenicity and adjuvanicity of peptide antigens following intranasal immunization.

"The use of peptides for various aspects of medical science has been a significant advance. Peptide-based vaccines are promising, but weak immunogenic potency is impeding the clinical application. We have remarkably enhanced the immunogenicity of peptide antigens by addition of motifs that bind to cell attachment proteins, such as arginine-glysine-aspartate (RGD), to the amino acid sequence," researchers in Japan report.

"The modified peptides induced antigen-specific serum antibodies by intranasal immunization...

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Source: Vaccine Weekly (2004-02-18)

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