Cytomegalovirus Vaccine

Glycoprotein B DNA vaccine prevents congenital cytomegalovirus transmission

Published in Vaccine Weekly, March 10th, 2004

Preconception vaccination with a glycoprotein B (GB) DNA vaccine protects against cytomegalovirus (CMV) transmission in the guinea pig model of congenital CMV infection.

"DNA vaccines expressing the guinea pig cytomegalovirus (GPCMV) homologs of the glycoprotein B (gB) and UL83 proteins were evaluated for protection against congenital GPCMV infection. After four doses of DNA administered by epidermal (gene gun) route, all guinea pigs developed enzyme-linked immunosorbent assay (ELISA) antibody and, for gB-vaccine recipients, neutralizing antibody. Dams were challenged with 1 x 10⁴ plaque-forming units of GPCMV in the third trimester," scientists in the United...

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Source: Vaccine Weekly (2004-03-10)

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