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Malaria Vaccine

Malaria-infected red blood cell antigens show promise as vaccine candidates

Published in Vaccine Weekly, March 24th, 2004

Scientists have investigated the relation of binding of immunoglobulin G to Plasmodium falciparum-infected erythrocytes with parasite endemicity and antibody responses to conserved antigen in immune individuals.

According to published research from Senegal and France, "To investigate the potential for use of a well-established strain of Plasmodium falciparum as a reference strain for infected red blood cell (IRBC) surface reactivity, we monitored the binding of specific immunoglobulin G (IgG) from immune individuals to the reference Knob-positive FCR3 strain by flow cytometry. To permit interassay comparison for 162 plasma samples drawn after the rainy...

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