Rotavirus Vaccine

HIV-1 Tat peptide-rotavirus enterotoxin protein stimulates immune response

Published in Vaccine Weekly, March 31st, 2004

Co-immunization with an HIV-1 Tat transduction peptide-rotavirus enterotoxin fusion protein stimulates a Th1 mucosal immune response in mice.

According to published research from the United States, "The cholera toxin B subunit (CTB) and a 12-aa HIV-1 Tat transduction peptide were genetically linked to a 90-aa peptide from the murine rotavirus non-structural enterotoxin protein (NSP4) for comparison of receptor directed and transduction peptide mediated antigen targeting to the gut-associated lymphoid tissues for enhanced protection against rotavirus infection. Oral immunization with Tat-NSP4₉₀ fusion protein isolated from Escherichia coli generated...

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Source: Vaccine Weekly (2004-03-31)

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