HIV/AIDS Vaccine

High-mannose-type oligosaccharides bind to human antibody 2G12

Published in Vaccine Weekly, April 7th, 2004

High-mannose-type oligosaccharides bind to human antibody 2G12, which has implications for HIV-1 vaccine design.

According to a study from the United States, "Human antibody 2G12 broadly neutralizes human immunodeficiency virus type 1 (HIV-1) isolates and shows protective activity against viral challenge in animal models. Previous mutational analysis suggested that 2G12 recognized a novel cluster of high-mannose type oligosaccharides on HIV-1 gp120. To explore the carbohydrate antigen for HIV-1 vaccine design, we have studied the binding of 2G12 to an array of HIV-1 high-mannose type oligosaccharides by competitive ELISAs and found that Man₉ GlNAc is 210- and...

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Source: Vaccine Weekly (2004-04-07)

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