Vaccinia Vaccine

Vaccinia virus infections treated with ether lipid esters of cidofovir

Published in Vaccine Weekly, April 7th, 2004

Cowpox and vaccinia virus infections in mice were treated with ether lipid esters of cidofovir.

According to recent research from the United States, "Four newly synthesized ether lipid esters of cidofovir (CDV), hexadecyloxypropyl-CDV (HDP-CDV), octadecyloxyethyl-CDV (ODE-CDV), oleyloxypropyl-CDV (OLP-CDV), and oleyloxyethyl-CDV (OLE-CDV), were found to have enhanced activities against vaccinia virus (W) and cowpox virus (CV) in vitro compared to those of CDV. The compounds were administered orally and were evaluated for their efficacies against lethal CV or W infections in mice."

"HDP-CDV, ODE-CDV, and OLE-CDV were effective at preventing mortality...

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Source: Vaccine Weekly (2004-04-07)

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