DNA Vaccine

Bacteria-mediated DNA transfer in gene therapy and vaccination reviewed

Published in Vaccine Weekly, April 21st, 2004

Scientists review bacteria-mediated DNA transfer in gene therapy and vaccination in a recent issue of Expert Opinion on Biological Therapy.

According to researchers in Germany, "The use of live attenuated bacterial vaccine strains allows the targeted delivery of macromolecules to mammalian cells and tissues via the mucosal route. Depending on their specific virulence mechanisms and inherent metabolic preferences, bacteria invade certain cell types and body niches where they consequently deliver their cargo. Recently, the ability of attenuated strains of Salmonella, Shigella, and Yersinia species, as well as Listeria monocytogenes and...

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Source: Vaccine Weekly (2004-04-21)

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