HIV/AIDS Vaccine

HIV-1 infection blocked via CCR5 and CXCR4 receptors

Published in Vaccine Weekly, April 21st, 2004

HIV-1 infection was blocked via CCR5 and CXCR4 receptors by acting in trans on the CCR2 chemokine receptor.

"The identification of chemokine receptors as HIV-1 coreceptors has focused research on developing strategies to prevent HIV-1 infection. We generated CCR2-01, a CCR2 receptor-specific monoclonal antibody that neither competes with the chemokine CCL2 for binding nor triggers signaling, but nonetheless blocks replication of monotropic (R5) and T-tropic (X4) HIV-1 strains. This effect is explained by the ability of CCR2-01 to induce oligomerization of CCR2 with the CCR5 or CXCR4 viral coreceptors," investigators in Spain report.

"HIV-1 infection...

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Source: Vaccine Weekly (2004-04-21)

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