Polio Vaccine
Only Sabin type 3 polio vaccine strain mutation reduces viral growth
Published in Vaccine Weekly, May 5th, 2004
"Initiation of poliovirus (PV) protein synthesis is governed by an internal ribosome entry segment structured into several domains including domain V, which is accepted to be important in PV neurovirulence because it harbors an attenuating mutation in each of the vaccine strains developed by A. Sabin. To better understand how these single point mutations exert their effects, we placed each of them into the same genomic context, that of PV type 1," scientists writing in the Journal of Biological Chemistry report.
"Only the mutation...
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Source: Vaccine Weekly (2004-05-05)
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