Vaccine Development
Modification of cholera toxin B subunit enhances expression in plants
Published in Vaccine Weekly, May 5th, 2004
"The cholera toxin B subunit (CTB) contains five identical polypeptides and targets glycosphingolipid receptors on eukaryotic cell surfaces. Increased expression of CTB in plants is critical for the development of edible vaccines. In this study, the coding sequence of the CTB gene was optimized, based on the modification of codon usage to that of tobacco plant genes and the removal of mRNA-destabilizing sequences," scientists in South Korea report.
"The synthetic CTB gene was cloned into a plant expression vector and expressed in tobacco plants under the...
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Source: Vaccine Weekly (2004-05-05)
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