HIV/AIDS
microRNA-designed hairpins increases RNA interference
Published in Vaccine Weekly, May 26th, 2004
"Post-transcriptional inhibition of HIV-1 replication can be achieved by RNA interference (RNAi). The cellular expression of short interfering RNA (siRNA) or short hairpin RNA (shRNA) homologous to regions of the HIV-1 genome decreases viral replication by the selective degradation of targeted RNA," wrote scientists at Brown University.
Results "demonstrate that another class of noncoding regulatory RNA, termed microRNA (miRNA), can be used to deliver antiviral RNAi," investigators in the United States report. By incorporating sequences encoding siRNA targeting the HIV-1 transactivator protein...
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Source: Vaccine Weekly (2004-05-26)
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