DNA Vaccine
DNA dry powder for non-viral gene delivery prepared by freeze-drying
Published in Vaccine Weekly, June 2nd, 2004
According to a study from Taiwan, "This study investigates the feasibility of using the process of spray-freeze drying (SFD) to produce DNA dry powders for non-viral gene delivery. The effect of protective agents was assessed on the stability of DNA dry powders after SFD. The process of SFD had adverse effects on the tertiary structure of DNA with the protective agents of sucrose, trehalose and mannitol. With the protection of these sugars, a band corresponding to the linear form of DNA was observed during gel electrophoresis between the supercoiled form (SC) and the open circular (OC)...
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Source: Vaccine Weekly (2004-06-02)
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