Published in Vaccine Weekly, June 2nd, 2004
According to recent research published in the journal Trends in Immunology, "The protective role of CD8+ cytotoxic T lymphocytes (CTLs) in HIV-1 infection has prompted an emphasis on generating virus-specific CTLs by vaccination, whereas the determinants of antiviral efficiency remain undefined. The general strategy of many vaccines is to maximize the breadth of CTL responses. However, patterns of changing CTL specificity and viral mutation in natural infection, in addition to data from macaque and in vitro studies, suggest that a more focused approach might optimize...
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