Encephalomyelitis
Protective encephalomyelitis DNA vaccine linked to IFN-beta induction
Published in Vaccine Weekly, June 9th, 2004
"DNA vaccines encoding encephalitogenic peptides protect against subsequent development of rat experimental autoimmune encephalomyelitis (EAE) through unknown mechanisms. We investigated immune cell phenotypes at different time points after DNA vaccination with vaccine encoding myelin oligodendrocyte glycoprotein peptide 91-108 and subsequent induction of EAE," researchers in Sweden report.
"In protected rats, we observed: no alterations in antigen-specific Th2 or TO responses; reduced MHC II expression on splenocytes early after EAE...
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Source: Vaccine Weekly (2004-06-09)
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