Melanoma Vaccine
Enhanced tumor response to dendritic cells without CD8+ cells reported
Published in Vaccine Weekly, June 16th, 2004
According to a study from the United States, "Wild-type mice immunized with MART-1 melanoma antigen-engineered dendritic cells (DC) generate strong antigen-specific immunity that has an absolute requirement for both CD8+ and CD4+ T cells. DC administration to CD8alpha knockout mice displayed unexpectedly enhanced levels of protection to tumor challenge despite this deficiency in CD8+ T cells and the inability to mount MHC class I-restricted immune responses."
"This model has the following features: antitumor protection is antigen independent; had an...
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Source: Vaccine Weekly (2004-06-16)
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