Published in Vaccine Weekly, June 16th, 2004
"Alphaviral replicons can increase the efficacy and immunogenicity of naked nucleic acid vaccines. To study the impact of apoptosis on this increased effectiveness, we co-delivered an anti-apoptotic gene (BCI-XL ) with the melanocyte/melanoma differentiation antigen TRP-1. Although cells co-transfected with Bcl-XL lived longer, produced more antigen, and elicited increased antibody production in vivo, co-delivery of pro-survival BCI-XL with antigen significantly reduced the ability of the replicase-based vaccine to protect against an...
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