Reproductive Health

Human antisperm antibody response in SCID mice is complex

Published in Vaccine Weekly, June 30th, 2004

Scientists outline the complexity of the human antisperm antibody response in SCID mice in a recent issue of Andrologia.

"Human peripheral blood mononuclear (PBMs) cells were introduced into the peritoneal cavity of severely-combined immunodeficient (SCID) mice in concentrations of 2.5-4.0 x 10⁷ cells per mouse. Whole mononuclear cell suspensions were used either unstimulated or following primary in vitro culture with human spermatozoa. In some experiments, immunodepletion of CD8+ cells was carried out prior to grafting. Lymphocytes were obtained from nonsensitized (to antigen) human subjects or from individuals who were primed in vivo (vasectomized...

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Source: Vaccine Weekly (2004-06-30)

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