Vaccine Development
CD8+ T cell cross-priming occurs via transfer of proteasome substrates
Published in Vaccine Weekly, July 21st, 2004
"'Cross-priming' describes the activation of naive CD8+ T cells by professional antigen-presenting cells that have acquired viral or tumor antigens from 'donor' cells. Antigen transfer is believed to be mediated by donor cell-derived molecular chaperones bearing short peptide ligands generated by proteasome degradation of protein antigens. We show here that cross-priming is based on the transfer of proteasome substrates rather than peptides," investigators in the United States report.
"These findings are potentially important for the rational design of vaccines that elicit CD8+ T...
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Source: Vaccine Weekly (2004-07-21)
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