Botulism Vaccine

Vaccination with botulinum neurotoxin fragments prevents botulism

Published in Vaccine Weekly, August 4th, 2004

Vaccination with botulinum neurotoxin fragments prevents botulism.

"Mice and ducks were subcutaneously immunized with recombinant whole heavy (H) chains of Clostridium botulinum type C and D neurotoxins, which were expressed as glutathione S-transferase fusion proteins. In the case of mice, it was confirmed that two immunizations with type C- and D-H chains, 10 mcg each time, significantly increased the specific antibodies against 100-kDa H chains of type C and D neurotoxins in an immunoblot analysis and an enzyme-linked immunosorbent assay, respectively," investigators in Japan report.

"The mice immunized with type G and D-H chains showed no...

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Source: Vaccine Weekly (2004-08-04)

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