Cancer Vaccine

SSX-2 epitope presented by dendritic cells to CD4+ T cells identified

Published in Vaccine Weekly, August 4th, 2004

Scientists have identified an SSX-2 epitope presented by dendritic cells to circulating autologous CD4+ T cells.

According to recent research from the United States, "Accumulating evidence supports the requirement for both tumor-specific CD8+ and CD4+ T cell responses for efficient tumor rejection to occur. Because of its expression in different tumor types, the cancer/testis antigen encoded by the synovial sarcoma X breakpoint 2 (SSX-2) gene is among the most relevant candidates for the development of generic cancer vaccines. The immunogenicity of SSX-2 has been previously corroborated by detection of specific humoral and CD8+ T cell responses in cancer...

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Source: Vaccine Weekly (2004-08-04)

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