Vaccine Development

Antigen distribution in mono-valent and combination vaccines reported

Published in Vaccine Weekly, August 4th, 2004

Researchers have determined the distribution of adsorbed antigen in mono-valent and combination vaccines.

According to recent research published in the journal Vaccine, "The distribution of alpha-casein, bovine serum albumin (BSA), myoglobin, and recombinant protective antigen (rPA) in mono-valent and combination vaccines containing aluminum hydroxide adjuvant was studied by fluorescence microscopy and flow cytometry. Green and red fluorescent probes were conjugated to the antigens. Adsorption isotherms of the fluorescently labeled proteins to aluminum hydroxide adjuvant demonstrated that incorporation of the fluorescent probe did not significantly affect the...

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Source: Vaccine Weekly (2004-08-04)

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