Vaccine Safety

Methodological issues arising from reviews of vaccine safety outlined

Published in Vaccine Weekly, August 4th, 2004

Scientists outline the methodological issues arising from systematic reviews of the evidence of safety of vaccines in a recent issue of Vaccine.

According to a study from England, "Adaptations to the recognized methods of systematic reviewing are required when addressing questions about safety, particularly about rare and/or long-term serious adverse events. Conducting a systematic review of vaccine safety requires the implementation of novel strategies for locating studies, the use of experimental instruments to assess the quality of non-randomized studies, and the employment of pooling methods for non-randomized data, where appropriate."

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Source: Vaccine Weekly (2004-08-04)

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