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Vaccine Weekly

Susan Hasty, Publisher

Table of Contents . . . August 11th, 2004

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Vaccine Weekly | Other Publications

Anthrax Vaccine - Antibodies against anthrax protective antigen promote macrophage death

Breast Cancer Vaccine - IL-12-engineered allogeneic cell vaccine prevents breast cancer

Malaria Vaccine - Antibodies against MAEBL ligand domains inhibit sporozoite development

Malaria Vaccine - Responses to antigen of Plasmodium linked to malaria immunity

Toxoplasmosis Vaccine - MVA ROP2 vaccinia virus is vaccine candidate for toxoplasmosis

AIDS/HIV Therapy - Protective T-cell epitope in p15gag of leukemia virus identified

Adeno-Associated Virus - Virus type antibodies inhibit recombinant AAV2-mediated gene transfer

Alzheimer Disease - Study says vaccine treatment slowed memory slide in Alzheimer patients

Anthrax Vaccine - Immunological memory promotes immunity by anthrax antigen-based vaccine

Ataxia-Telangiectasia - Pneumococcal vaccine elicits antibody response to ataxia-telangiectasia

Avian Influenza - Bird flu resurfaces in parts of Indonesia, prompts vaccination

Bluetongue Virus - Arbovirus nonstructural protein plays role in cellular pathogenesis

Botulinum Toxin - Glu212 carboxylate plays key role in botulinum toxin catalytic pathway

Breast Cancer Vaccine - Method to quantify immune response in cancer patients developed

Brucellosis - Oral vaccine may protect against respiratory disease, potential biowarfare agent

Business Update - Biopharmaceutical company to expand manufacturing facility for vaccine products

Business Update - CRO announces $1.4 million of new business contracts

Business Update - Engineering group announces contract from vaccine business

Cancer Research - Food and drug retailer funds professorship for prostate cancer research at UCSF

Cancer Therapy - Vet school professor using gene therapy to battle cancerous tumors

Cancer Vaccine - CXCR3 plays pivotal role in melanoma cell metastasis to lymph nodes

Cancer Vaccine - MAGE-1 peptide recognized by T cells on HLA-B*5701 tumors identified

Cancer Vaccine - Profile of tumor antigens on breast and pancreatic cancer cells created

Cancer Vaccine - Progress on new vaccine strategies to treat and prevent cancer reviewed

Candidiasis - Toll-like receptor 2 dispensable for resistance to Candida albicans

Chagas Disease - Autoimmune response induced by Trypanosoma cruzi proteins

Collaborations - Agreement signed to develop disposable-cartridge jet injection system

DPT Vaccine -  Withania somnifera extract modulates immune response to DPT vaccine

Drug Development - Second clinical trial of anti-smoking vaccine has successful results

Encephalitis Vaccine - Stimulation of immune system by different TBE-virus vaccines reported

Encephalitis Vaccine - Sub-genomic replicons of tick-borne encephalitis virus constructed

Gastroenterology - ROTARIX vaccine approved by Mexican authorities for gastroenteritis in infants

Gene Therapy - Polymeric nanoparticles used as gene carriers in gastric mucus

H. Pylori Prevention - NIAID grant awarded to continue development of H. pylori vaccine

HIV/AIDS Vaccine - Biopharma company reports encouraging preliminary HIV/AIDS vaccine results

HIV/AIDS Vaccine - First patients enrolled in HIV vaccine trial

HIV/AIDS Vaccine - Preliminary EP HIV-1090 trial data presented at international AIDS conference

HIV/AIDS Vaccine - Tomatoes may offer edible AIDS vaccine

Helicobacter Pylori - Scientists discover new intricacies in how ulcer bugs stick to stomach

Helicobacter Vaccine - Antigen from H. pylori urease used for vaccine

Helicobacter Vaccine - Vaccine safe and effective against H. pylori infection in dog model

Hepatitis - Hepatitis as travelers' disease reviewed

Hepatitis B Vaccine - Barriers to hepatitis B vaccination in Korean Americans identified

Hepatitis C Vaccine - Chimpanzees infected hepatitis C lack dendritic cell impairment

Hepatitis C Vaccine - Clearance of hepatitis C viremia associated with cellular immunity

Herpesvirus Vaccine - Herpesvirus CJ83193 is effective vaccine against HSV-1 infection

Human Papillomavirus Vaccine - Two novel human papillomavirus-16 E7 T helper epitopes identified

Immunization - Merck Vaccine Network-Africa Training Center in Kenya conducts training class

Immunology - Alum-induced myeloid cell population promotes B cell immune responses

Immunology - Drug company reports data on HIV research at international AIDS conference

Immunology - Immunological memory in humans reviewed

Immunology - Patients' cells from tumors, immune system merged for customized cancer therapy

Immunology - T cells from Anaplasma protein vaccinees recognize epitopes in MSP3

Influenza - New patch may enhance effects of flu virus vaccine in aging population

Influenza - Positive results announced from FluINsure field efficacy study

Influenza Vaccine - Influenza vaccination by race among disabled women reported

Legal Issues - CytRx provides update on Massachusetts Ethics Commission preliminary inquiry

Leishmaniasis Vaccine -  Leishmania mutant able to survive as amastigotes within macrophages

Leishmaniasis Vaccine - Hybrid protein vaccine partially protects against leishmaniasis

Leishmaniasis Vaccine - Sub-clinical infection effective to obtain anti-Leishmania antibodies

Leukemia Vaccine - Peptide immunogens mimic coiled region of T-cell leukemia virus subunit

Lyme Disease Vaccine - Lyme disease vaccines do not respond to conserved region of Borrelia

Malaria Vaccine - Antibody recognition of Plasmodium surface antigens conserved

Malaria Vaccine - Fitting peptides into MHC-TCR complex indicates malaria protection

Malaria Vaccine - Highly immunogenic prime-boost regimens reported for malaria vaccine

Malaria Vaccine - Malaria prevention and therapy reviewed

Medical Waste - Vaccine wastage determined during polio immunization program in India

Melanoma - Vaccine boosts immunity against cancer target

Meningococcal Vaccine - Responses to meningococcal group C conjugate vaccines determined

Personnel - Linda Staley named vice president, IT for cancer biotech

Pertussis Vaccine -  Bordetella pertussis intranasal vaccine close to development

Pertussis Vaccine - Pertussis toxin antibodies suppressed after Bordetella colonization

Poliomyelitis - Nigerian authorities battle polio outbreak in Muslim region

Prion Disease - Recombinant prion protein with mutation inhibits PrPSc replication

Respiratory Syncytial Virus - RSV lacking C-terminal of G protein are immunogenic and attenuated

Respiratory Syncytial Virus - Respiratory syncytial virus protein not needed for disease

Rotavirus Vaccine - Antibodies to rotavirus proteins in vaccinated infants determined

Rotavirus Vaccine - Rotavirus IgA stimulated by doses of quadrivalent rotavirus vaccine

Rotavirus Vaccine - Time series of deaths due to diarrhea in Brazilian children reported

SARS Vaccine - Assembly of SARS coronavirus-like particles described

SARS Vaccine - SARS cytotoxic T lymphocyte vaccine candidates identified

Schistosomiasis - Schistosome transcriptomes provide insights into schistosomiasis

Schistosomiasis Vaccine - Genome and genomics of schistosomes reviewed

Smallpox Vaccine - Biochemical and functional analyses of smallpox growth factor conducted

Smallpox Virus - PCR method to detect orthopoxviruses and smallpox virus developed

Streptococcus Vaccine - Diverse Ig gene usage found in antibody response to Streptococcus

Streptococcus Vaccine - Live Lactococcus vaccine protects against Streptococcus infection

Tuberculosis - Mycobacterial lipoprotein mitogenicity not linked to antiprotection

Tularemia Vaccine -  Francisella tularensis strains prevent maturation of phagosomes

Vaccine Delivery -  Salmonella mutants deliver antigen to antigen-presenting cells

Vaccine Development - Structure-immunogenicity relationships of therapeutic proteins reviewed

Vaccine Efficacy - Antibodies after vaccination not reduced by recurrent otitis media

Vaccine Efficacy - Risk factors for diarrhea in children in rural area of Uganda reported

Vaccine Safety - CDC reviews procedures to promote vaccine safety

Vaccine Safety - Global perspective on vaccine safety published

Vaccine Safety - Public confidence in vaccines enhanced by oversight of vaccine safety

Vaccine Vector - Adenoviral vector production kinetics in perfusion cultures determined

Vaccines - Boostrix BLA submitted

Vaccinia Vaccine - I7 protein required for proteolytic processing of vaccinia virus membrane

Varicella Vaccine - Varicella vaccination of healthy children poses challenge for Europe

Vector Development - Host cell gene expression changes after vaccinia virus infection

Vector Development - Thiol-reactive lipopeptide adjuvants in liposomes have mitogenic effect

Virology - Anatomical features of antiviral immunity in respiratory tract reviewed

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