Botulinum Toxin

Glu212 carboxylate plays key role in botulinum toxin catalytic pathway

Published in Vaccine Weekly, August 11th, 2004

A structural analysis of botulinum neurotoxin type E catalytic domain and its mutant Glu212->Gln revealed the pivotal role of the Glu212 carboxylate in the catalytic pathway.

According to recent research from the United States, "The seven serotypes of botulinum neurotoxins (A-G) produced by Clostridium botulinum share significant sequence homology and structural similarity. The functions of their individual domains and the modes of action are also similar. However, the substrate specificity and the peptide bond cleavage selectivity of their catalytic domains are different. The reason for this unique specificity of botulinum neurotoxins is still baffling....

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Source: Vaccine Weekly (2004-08-11)

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