Anthrax Vaccine

Antibodies against anthrax protective antigen promote macrophage death

Published in Vaccine Weekly, August 11th, 2004

A subset of monoclonal antibodies against anthrax protective antigen increases lethal toxin-mediated killing of murine macrophages.

"We investigated the ability of using monoclonal antibodies (MAbs) against anthrax protective antigen (PA), an anthrax exotoxin component, to modulate exotoxin cytotoxic activity on target macrophage cell lines. Anthrax PA plays a critical role in the pathogenesis of Bacillus anthracis infection. PA is the cell-binding component of the two anthrax exotoxins: lethal toxin (LeTx) and edema toxin. Several MAbs that bind the PA component of LeTx are known to neutralize LeTx-mediated killing of target macrophages," scientists writing in...

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Source: Vaccine Weekly (2004-08-11)

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