Hepatitis C Vaccine

Chimpanzees infected hepatitis C lack dendritic cell impairment

Published in Vaccine Weekly, August 11th, 2004

Chimpanzees chronically infected with hepatitis C virus lack phenotypic and functional impairment in dendritic cells.

"Dendritic cells (DCs), which are potent antigen-presenting cells (APCs), are used as adjuvants for the treatment of cancer and infectious diseases in human and nonhuman primates, with documented clinical efficacy. The hepatitis C virus (HCV)-chimpanzee model is the best available model for testing the immunotherapeutic effects of DCs in the setting of a chronic infection, as chimpanzees develop a persistent infection resembling that seen in humans. However, several reports have suggested that DCs derived from chronically infected individuals or nonhuman...

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Source: Vaccine Weekly (2004-08-11)

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