Respiratory Syncytial Virus

RSV lacking C-terminal of G protein are immunogenic and attenuated

Published in Vaccine Weekly, August 11th, 2004

Recombinant respiratory syncytial viruses lacking the C-terminal third of the attachment (G) protein are immunogenic and attenuated in vivo and in vitro.

"The design of attenuated vaccines for respiratory syncytial virus (RSV) historically focused on viruses made sensitive to physiologic temperature through point mutations in the genome. These prototype vaccines were not suitable for human infants primarily because of insufficient attenuation, genetic instability, and reversion to a less-attenuated phenotype. We therefore sought to construct novel attenuated viruses with less potential for reversion through genetic alteration of the attachment G protein," scientists...

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Source: Vaccine Weekly (2004-08-11)

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