Tularemia Vaccine

Francisella tularensis strains prevent maturation of phagosomes

Published in Vaccine Weekly, August 11th, 2004

Virulent and avirulent strains of Francisella tularensis prevent acidification and maturation of their phagosomes and escape into the cytoplasm in human macrophages.

According to recent research published in the journal Infection and Immunity, "Francisella tularensis, the agent of tularemia, is an intracellular pathogen, but little is known about the compartment in which it resides in human macrophages. We have examined the interaction of a recent virulent clinical isolate of F. tularensis subspecies tularensis and the live vaccine strain with human macrophages by immunoelectron and confocal immunofluorescence microscopy."

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Source: Vaccine Weekly (2004-08-11)

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