Tuberculosis Vaccine

Epitopes that improve specificity of M. tuberculosis assay identified

Published in Vaccine Weekly, August 25th, 2004

Scientists have identified specific T-cell epitopes that improve the specificity of immunoassay-based diagnosis of Mycobacterium tuberculosis infection.

"The currently used method for immunological detection of tuberculosis infection, the tuberculin skin test, has low specificity. Antigens specific for Mycobacterium tuberculosis to replace purified protein derivative are therefore urgently needed. We have performed a rigorous assessment of the diagnostic potential of four recently identified antigens (Rv2653, Rv2654, Rv3873, and Rv3878) from genomic regions that are lacking from the Mycobacterium bovis bacillus Calmette-Guerin (BCG) vaccine strains...

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Source: Vaccine Weekly (2004-08-25)

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