Metapneumovirus

Two major human metapneumovirus lineages are highly related antigenically

Published in Vaccine Weekly, August 25th, 2004

The two major human metapneumovirus genetic lineages are highly related antigenically, and the fusion (F) protein is a major contributor to this antigenic relatedness.

"The growth properties and antigenic relatedness of the CAN98-75 (CAN75) and the CAN97-83 (CAN83) human metapneumovirus (HMPV) strains, which represent the two distinct HMPV genetic lineages and exhibit 5 and 63% amino acid divergence in the fusion (F) and attachment (G) proteins, respectively, were investigated in vitro and in rodents and nonhuman primates. Both strains replicated to high titers ({{>=}}6.0 log₁₀ ) in the upper respiratory tract of hamsters and to moderate titers...

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Source: Vaccine Weekly (2004-08-25)

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