Published in Vaccine Weekly, August 25th, 2004
According to a study from the United States, "CD8+ T lymphocytes have been shown to be involved in controlling poxvirus infection, but no protective cytotoxic T-lymphocyte (CTL) epitopes are defined for variola virus, the causative agent of smallpox, or for vaccinia virus. Of several peptides in vaccinia virus predicted to bind HLA-A2.1, three - VETFsm(498-506), A26L(6-14), and HRP2(74-82) - were found to bind HLA-A2.1."
"Splenocytes from HLA-A2.1 transgenic mice immunized with vaccinia...
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