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Vaccine Weekly

Susan Hasty, Publisher

Table of Contents . . . September 1st, 2004

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Vaccine Weekly | Other Publications

Otitis Media Vaccine -  Streptococcus pneumoniae neuraminidase protects against otitis media

Parkinson Disease - Immunization protects dopaminergic neurons in model of Parkinson disease

Pertussis Vaccine - No evidence found linking encephalopathy to pertussis vaccination

Pneumococcal Vaccine - Killed nonencapsulated cells protect mice against pneumococcal colonization

Prion Disease - Prion protein domains elicit antibody responses against native molecule

AIDS/HIV Vaccine - Challenges in the search for HIV vaccine outlined

AIDS/HIV Vaccine - DNA prime-MVA boost HIV vaccine tailored for eastern and central Africa

AIDS/HIV Vaccine - T cell-based control of SIV replication in AIDS vaccine trial reported

Allergy Medicine - Quaternary ammonium compounds exhibit adjuvant effect in murine model

Allergy Medicine - Tolerance in T cells accompanied by effector function in lymphoid organs

Alzheimer Disease - Amyloid accumulation in Alzheimer disease is response to chronic stress

Alzheimer Disease Vaccine - Testing of Alzheimer vaccines needed in non-murine models

Autoimmune Disease - Prostaglandin E2 receptors up-regulated in peritoneal macrophages

Breast Cancer Vaccine - Farnesyl transferase inhibitors show promise as therapies for breast cancer

Breast Cancer Vaccine - Peptides inducing immune responses in breast cancer patients identified

Breast Cancer Vaccine - Tamoxifen and soluble tumor-associated antigens suppress breast cancer

Brucellosis Vaccine - Vaccine protects mice against virulent Brucella melitensis

Business & Finance - Pharma company reports second quarter 2004 results

Business Update - Generics producer granted rights for fluconazole, intends to file antiretroviral

Cancer Therapy - Biotechnology company and ViroTarg sign anticancer license agreement

Cancer Therapy - Pharma company announces publication of study examining Talabostat

Cancer Vaccine - Antigen-loading strategies of dendritic cells for cancer vaccines compared

Cancer Vaccine - CD4+ responses identified in patient vaccinated with NY-ESO-1

Cancer Vaccine - Epithelial cancer-related antigens applicable for peptide-based immunotherapy

Cancer Vaccine - Exosomes from plasmacytoma cells show promise as tumor vaccine

Cancer Vaccine - Monoclonal antibodies recognize idiotypic immunoglobulins of lymphoma cells

Cancer Vaccine - Thymus-leukemia antigen acts as tumor-specific antigen

Cancer Vaccine - Viral chemokine fusions trigger antitumor immunity independent of chemotaxis

Chagas Disease - Trypomastigote challenge of T. cruzi infected mice reduces parasitemia

Chickenpox - Varicella vaccine reduces contagiousness of chickenpox

Cholera Vaccine -  V. cholerae polysaccharide fragments are immunogenic in mice

Cryptococcus - Antibodies to Cryptococcus neoformans infection are nonprotective

Cytomegalovirus - Gender differences exist in cytokine secretion from cytomegalovirus infection

Cytomegalovirus Vaccine - CD8+ T-cell immunity to cytomegalovirus reviewed

Cytomegalovirus Vaccine - Cytomegalovirus-specific cellular immune responses reviewed

Cytomegalovirus Vaccine - Lentiviral vector encoding cytomegalovirus protein identifies epitopes

Cytomegalovirus Vaccine - Progress being made toward developing cytomegalovirus peptide vaccine

Diagnostics - Monocyte activation test for parenteral drug contaminants developed

Drug Delivery - Positive results reported: Electroporation-enabled DNA delivery sans anesthesia

Drug Development - Tobacco promising "factory" for biopharmaceuticals

Entamoeba Vaccine -  Entamoeba lectin epitopes recognized by human IgA antibodies identified

Finance - Immunotherapy company's second-quarter revenue dips

Finance - Maker of COLD-EEZE reports second quarter results

Francisella - Hsp60 plus copurified lipopolysaccharide protects against F. tularensis

Guillain-Barre Syndrome - Link between Guillain-Barre syndrome and hepatitis A vaccine reported

Hepatitis A Vaccine - Inactivated hepatitis A vaccine effective in children with liver disease

Hepatitis B Vaccine - Hepatitis B vaccine plus lamivudine did not eliminate viral DNA

Immunization - Vaccination blitz: 13,312 inoculations over 2 1/2 days

Immunology - Method to monitor T cell responses during vaccine studies developed

Immunology - Methods to recover cells from ELISPOT immunoassay developed

Immunology - Tetramers with influenza hemagglutinin and EBV epitopes detect CD4+ T cells

Immunology - VIG product submitted for FDA approval

Immunotherapy - Cytokine staining to quantify specific T cell responses in macaques optimized

Immunotherapy - Human B cells are alternative source of efficient antigen-presenting cells

Influenza - CDC: Flu shot effective more than half of the time

Influenza - Company delivers first million doses of Fluvirin vaccine to U.S. distributors

Influenza - First influenza vaccine shipped to healthcare providers

Influenza Vaccine - Reassortment with avian influenza virus attenuates influenza virus

Influenza Virus - Antigenic and genetic evolution of influenza virus mapped

Lyme Disease Vaccine - Lyme borreliosis from infection to autoimmunity reviewed

Measles - CDC: Measles cases lowest since 1912

Measles Virus - Conformational flexibility in measles virus nucleocapsids visualized

Melanoma Vaccine - Efficacy of melanoma vaccines enhanced in the absence of B lymphocytes

Meningitis Vaccine - Mucosal vaccine against serogroup B meningococci developed

Microencapsulation - Effect of microsphere formulation on protein immunogenicity studied

Mucosal Immunization - Nasal antigen delivery augments antigen-specific T-cell clonal expansion

Mumps Virus - Method to quantify mumps virus RNA by one-step real-time RT-PCR developed

Neisseria - NadA diversity and carriage in Neisseria meningitidis reviewed

Paracoccidioidomycosis - Immunodominant epitopes from Paracoccidioides brasiliensis identified

Periodontal Disease - Antibody response by P. gingivalis and F. nucleatum modulated

Personnel - Caudill named chairman, CEO Gordon also named president at biopharm company

Personnel - Cerus appoints William J. Dawson as vice president, finance and CFO

Pertussis Vaccine - Epitope of Bordetella pertussis protein characterized

Pertussis Vaccine - Expression of pertussis toxin S1 subunit protects against pertussis toxin

Polio Vaccine - Mutated Sabin poliovirus shed after administration of oral poliovirus vaccine

Product Licensing - European patent for Vaxfectin adjuvant granted to biopharmaceutical company

Prostate Cancer Vaccine - Vaccine against LH-releasing fusion protein does not increase prostate cancer

Rabies Vaccine - The use of rabies immune globulin by emergency physicians

Respiratory Syncytial Virus - Nasal IgA important for protection from respiratory syncytial virus infection

SARS Research - Two antigenic epitopes on the SARS-CoV spike protein are identified

Salmonella Vaccine - Immune responses to killed Salmonella vaccine investigated

Salmonella Vaccine - Oral immunization with RfaH mutant protects mice against salmonellosis

Smallpox - FDA accepts BLA filing for Vaccinia Immune Globulin

Streptococcus - Early results show promise for strep vaccine

Streptococcus Vaccine -  Streptococcus pneumoniae epidemiology from Portugal aids vaccine choice

Survival & Mortality - Health care program lowers child and maternal mortality in Bangladesh

Tapeworm - Two antigens for Taenia solium tapeworm infection characterized

Toxoplasmosis Vaccine - Antigen-pulsed exosomes protect against Toxoplasma gondii infection

Tuberculosis Vaccine - Cellular response insufficient for long-term survival in TB patients

Tuberculosis Vaccine - Macrophage apoptosis in host immunity to mycobacterial infections reviewed

Tuberculosis Vaccine - T-cell epitopes on novel protective antigen of M. tuberculosis identified

Vaccine Adjuvant - DNA vaccine adjuvant does not skew Th1/Th2 polarization

Vaccine Adjuvant - Microparticle adjuvant formulation for plasmid DNA vaccines characterized

Vaccine Development - Antibody Fab with human-like framework regions obtained from phage library

Vaccine Development - Kinase activates ATF2 transcriptional activity by novel phosphorylation

Vaccine Development - Plant-derived hanatvirus virus nucleocapsid protein not immunogenic

Vaccine Development - Positive results announced from phase II trial of StreptAvax vaccine

Vaccine Safety - Neurodevelopmental disorders reported after thimerosal-containing vaccines

Vaccine Vector - Rabies virus nucleoprotein functions as carrier for foreign antigens

Vaccines - Scientists report headway with experimental strep vaccine

Varicella-Zoster Virus - HAART does not prevent herpes zoster infection in HIV-infected children

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