Published in Vaccine Weekly, September 1st, 2004
According to recent research published in the journal Endocrine-Related Cancer, "The ras family of proto-oncogenes are upstream mediators of several essential cellular signal transduction pathways involved in cell proliferation and survival. Point mutations of ras oncogenes result in constitutively active Ras and have been shown to be oncogenic. However, ras activation can occur in the absence of ras mutations secondary to upstream receptor activation. The first important step in Ras activation is famesylation by farnesyl transferase, and inhibitors of this enzyme have been...
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