Prion Disease
Prion protein domains elicit antibody responses against native molecule
Published in Vaccine Weekly, September 1st, 2004
"Recent reports suggest that immunity against the prion protein (PrP) retards transmissible spongiform encephalopathies progression in infected mice. A major obstacle to the development of vaccines comes from the fact that PrP is poorly immunogenic, as it is seen as self by the host immune system. Additional questions concern the immune mechanisms involved in protection and the risk of eliciting adverse reactions in the central nervous system of treated patients," researchers in France...
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Source: Vaccine Weekly (2004-09-01)
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