Paracoccidioidomycosis

Immunodominant epitopes from Paracoccidioides brasiliensis identified

Published in Vaccine Weekly, September 1st, 2004

In silico prediction of peptides binding to multiple HLA-DR molecules accurately identifies immunodominant epitopes from gp43 of Paracoccidioides brasiliensis frequently recognized in primary peripheral blood mononuclear cell responses from sensitized individuals.

"One of the major drawbacks limiting the use of synthetic peptide vaccines in genetically distinct populations is the fact that different epitopes are recognized by T cells from individuals displaying distinct major histocompatibility complex molecules. Immunization of mice with peptide (181-195) from the immunodominant 43-kDa glycoprotein of Paracoccidioides brasiliensis (gp43), the causative...

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Source: Vaccine Weekly (2004-09-01)

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