Polio Vaccine
Mutated Sabin poliovirus shed after administration of oral poliovirus vaccine
Published in Vaccine Weekly, September 1st, 2004
According to recent research published in the Journal of Infectious Diseases, "A uracil-to-cytosine point mutation at nucleotide (nt) 472 of Sabin oral poliovirus vaccine (OPV) type 3 is found in conjunction with vaccine-associated paralytic poliomyelitis (VAPP). Direct RNA extraction and mutant analysis by polymerase chain reaction and restriction enzyme cleavage were used to identify this point mutation in clinical samples. A total of 238 stool samples were obtained from 28 healthy infants for 6 weeks after OPV...
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Source: Vaccine Weekly (2004-09-01)
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