Tuberculosis Vaccine
Cellular response insufficient for long-term survival in TB patients
Published in Vaccine Weekly, September 1st, 2004
"Mice that were transgenic for a T-cell receptor (TCR) specific for ovalbumin peptide323-339 (DO11.10) were able to survive an infection with Mycobacterium tuberculosis for approximately 80 days. This limited early control of infection was associated with gamma interferon production, inducible nitric oxide synthase expression within the lung, and an influx of clonotypic lymphocytes. The control of M. tuberculosis was lost in DO11.10 mice bred in a rag mutant background,...
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Source: Vaccine Weekly (2004-09-01)
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