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AIDS/HIV Vaccine
Multi-subtype gp160 DNA immunization induces neutralizing anti-HIV antibodies
September 8th, 2004
Multi-subtype gp160 DNA immunization induces broadly neutralizing anti-HIV antibodies. "A highly desirable feature for an human immunodeficiency virus type 1 (HIV-1) vaccine is the ability to induce broadly reactive anti-envelope antibodies that can neutralize primary HIV-1 isolates. Two immunizations with an HIV-1 envelope-encoding plasmid together with recombinant granulocyte macrophage colony-stimulating factor (rGM-CSF) resulted in high antibody titers in mice. The antibody induction was further enhanced after immunization with genes encoding HIV-1 envelopes originating from subtypes A, B and C," scientists in Sweden report. "The sera from these...
Source: Vaccine Weekly (2004-09-08)
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