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Acanthamoeba Vaccine
Novel mannose-binding protein of Acanthamoeba characterized
September 8th, 2004
Scientists have characterized a novel mannose-binding protein of Acanthamoeba. "Acanthamoebae produce a painful, blinding infection of the cornea. The mannose-binding protein (MBP) of Acanthamoeba is thought to play a key role in the pathogenesis of the infection by mediating the adhesion of parasites to the host cells. We describe here the isolation and molecular cloning of Acanthamoeba MBP. The MBP was isolated by chromatography on the mannose affinity gel. Gel filtration experiments revealed that the Acanthamoeba lectin is an {{approx}}400-kDa protein that is constituted of multiple 130-kDa subunits," investigators in the United...
Source: Vaccine Weekly (2004-09-08)
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