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Alzheimer Disease Vaccine
Anti-beta-amyloid antibodies generated via phage display technology
September 8th, 2004
Scientists have generated anti-beta-amyloid antibodies via phage display technology. "The EFRH sequence, found to be the main anti-aggregating epitope corresponding to amino acids 3-6 of beta-amyloid peptide (A-betaP), was displayed on a phage and used as an antigen for immunization of mice, guinea pigs, and rabbits. The generated antibodies recognize the full-length A-betaP (1-40) and exhibit similar biological properties to antibodies raised against whole soluble peptide and/or fibrillar beta-amyloid," investigators in Israel report. "EFRH-phage immunization of a transgenic mouse model of Alzheimer's disease evokes antibodies able to dissolve...
Source: Vaccine Weekly (2004-09-08)
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