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Cancer Vaccine
Binding patterns reveal tumor-specific epitope of epithelial mucin
September 8th, 2004
Binding patterns of DTR-specific antibodies reveal a glycosylation-conditioned tumor-specific epitope of the epithelial mucin (MUC1). "Glycosylation determines essential biological functions of epithelial mucins in health and disease. We report on the influence of glycosylation of the immunodominant DTR motif of MUC1 on its antigenicity. Sets of novel glycopeptides were synthesized that enabled us to examine sole and combined effects of peptide length (number of repeats) and O-glycosylation with GalNAc at the DTR motif on the binding patterns of 22 monoclonal antibodies recognizing this motif, In case of unglycosylated peptides almost all antibodies bound better to...
Source: Vaccine Weekly (2004-09-08)
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