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Cancer Vaccine
Dendritic cell vaccine induces tumoricidal CD8+ cytotoxic lymphocytes
September 8th, 2004
Vaccination with dendritic cells pulsed in vitro with tumor antigen conjugated to cholera toxin efficiently induces specific tumoricidal CD8+ cytotoxic lymphocytes dependent on cyclic AMP activation of dendritic cells. "We investigated the development of CD8+ tumor-specific cytotoxic lymphocytes (CTL) and protection against tumor growth after vaccination with bone marrow-derived dendritic cells (DC) pulsed with a model protein ovalbumin conjugated to cholera toxin (OVA-CT) in 136 mice using E.G7 tumor cells expressing OVA257-264 peptide (SIINFEKL) as target cells in vitro and in vivo. Vaccination with, OVA-CT-pulsed DC concurrently induced strong CTL in...
Source: Vaccine Weekly (2004-09-08)
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