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Cancer Vaccine
Epigenetically altered tumor cell vaccine developed
September 8th, 2004
An epigenetically altered tumor cell vaccine has been developed. According to a study from the United States, "Functional inactivation of genes critical to immunity may occur by mutation and/or by repression, the latter being potentially reversible with agents that modify chromatin. This study was constructed to determine whether reversal of gene silencing, by altering the acetylation status of chromatin, might lead to an effective tumor vaccine. We show that the expression of selected genes important to tumor immunity, including MHC class II, CD40, and B7-1/2 are altered by treating tumor cells in vitro with a histone deacetylase inhibitor, trichostatin A...
Source: Vaccine Weekly (2004-09-08)
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