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Cancer Vaccine
T-cell responses in patients vaccinated with melanoma vaccine reported
September 8th, 2004
Researchers report the results of an analysis of T-cell responses in metastatic melanoma patients vaccinated with dendritic cells pulsed with tumor lysates in a recent issue of Cancer Immunology Immunotherapy. "In melanoma patients, CD8+ cytotoxic T cells have been found recognizing self-proteins of which the expression is restricted to the melanocytic lineage. These melanocyte differentiation antigens are expressed in normal melanocytes as well as in 80-100% of primary and metastatic melanoma. In this report, six HLA-A*0201-subtyped metastatic melanoma patients vaccinated with dendritic cells (DCs) pulsed with autologous tumor lysates and keyhole limpet...
Source: Vaccine Weekly (2004-09-08)
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