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DNA Vaccine
Bacteriophage lambda is highly stable DNA vaccine delivery vehicle
September 8th, 2004
Bacteriophage lambda is a highly stable DNA vaccine delivery vehicle. "The stability of whole bacteriophage X particles, used as a DNA vaccine delivery system has been examined. Phage were found to be highly stable undernormal storage conditions. In liquid suspension, no decrease in titer was observed over a 6-month period at 4 and -70 degrees C, and phage stability was unaffected by freeze/thawing. The measured half-life of phage in suspension was 36 days at 20 degrees C, 3.4 days at 37 degrees C and 2.3 days at 42 degrees C. Freeze drying of a phage suspension (with or without the stabilizers dry skim milk or trehalose) resulted in 5-20% residual viability,"...
Source: Vaccine Weekly (2004-09-08)
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