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Vaccine Weekly

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Epstein-Barr Virus



Epstein-Barr virus protein sufficient for transactivation of superantigen



September 8th, 2004

The Epstein-Barr virus latent membrane protein LMP-2A is sufficient for transactivation of the human endogenous retrovirus HERV-K18 superantigen.

According to a study from the United States, "Superantigens are microbial proteins that strongly stimulate T cells. We described previously that the Epstein-Barr virus (EBV) transactivates a superantigen encoded by the human endogenous retrovirus, HERV-K18. We now report that the transactivation is dependent upon the EBV latent cycle proteins."

"Moreover, LMP-2A is sufficient for induction of HERV-K18 superantigen activity," stated Natalie Sutkowski and colleagues at Tufts University.

...


Source: Vaccine Weekly (2004-09-08)

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