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Epstein-Barr Virus
Epstein-Barr virus protein sufficient for transactivation of superantigen
September 8th, 2004
The Epstein-Barr virus latent membrane protein LMP-2A is sufficient for transactivation of the human endogenous retrovirus HERV-K18 superantigen. According to a study from the United States, "Superantigens are microbial proteins that strongly stimulate T cells. We described previously that the Epstein-Barr virus (EBV) transactivates a superantigen encoded by the human endogenous retrovirus, HERV-K18. We now report that the transactivation is dependent upon the EBV latent cycle proteins." "Moreover, LMP-2A is sufficient for induction of HERV-K18 superantigen activity," stated Natalie Sutkowski and colleagues at Tufts University. ...
Source: Vaccine Weekly (2004-09-08)
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