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Gastroenterology Vaccine
Activity of E. coli phages have implications for phage therapy
September 8th, 2004
The in vitro and in vivo bacteriolytic activities of Escherichia coli phages have implications for phage therapy. "Four T4-like coliphages with broad host ranges for diarrhea-associated Escherichia coli serotypes were isolated from stool specimens from pediatric diarrhea patients and from environmental water samples. All four phages showed a highly efficient gastrointestinal passage in adult mice when added to drinking water. Viable phages were recovered from the feces in a dose-dependent way. The minimal oral dose for consistent fecal recovery was as low as 103 PFU of phage per mL of drinking water," investigators in Switzerland report. ...
Source: Vaccine Weekly (2004-09-08)
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