Helicobacter Vaccine

Regulatory T cells suppress H. pylori-reactive immunopathological T cells

Published in Vaccine Weekly, September 8th, 2004

CD4+CD25+ regulatory T cells induce antigen-specific in vitro suppression of murine Helicobacter pylori-reactive immunopathological T cells.

According to a study from Sweden, "A Helicobacter pylori-specific in vitro coculture system was established and used to study the role of CD4+CD25+ regulatory T cells (Treg) in gastritis development in mice with H. pylori infection. Effects of therapeutic immunization against H. pylori infection on the Treg function were also studied to better understand the mechanisms leading to postimmunization gastritis in these mice. Depletion of Treg led to extensive proliferation to H. pylori antigens of...

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Source: Vaccine Weekly (2004-09-08)

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