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Hepatitis B Vaccine
Hepatitis B surface S and preS2 antigens expressed in Solanum tuberosum
September 8th, 2004
Hepatitis B surface S and preS2 antigens have been expressed in tubers of Solanum tuberosum. According to recent research from South Korea, "In an attempt to develop an edible vaccine, we transformed a recombinant hepatitis B virus (HBV) gene encoding the middle protein of HBV that contains the surface S and preS2 antigen into potato by Agrobacterium-mediated transformation. The HBV gene was under control of either the CaMV 35S promoter, the double 35S promoter with the AlMV 5' non-translated leader sequence, or the tuber-specific patatin promoter." "HBV mRNA levels were higher with the 35S promoter than with the double 35S and patatin...
Source: Vaccine Weekly (2004-09-08)
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