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Inflammation



Wood smoke increases expression of two mucin genes in rat airways



September 8th, 2004

Wood smoke increases the expression of two mucin genes in rat airways.

"A short-term, time-dependent smoke exposure of rats in a nose-only chamber to burning wood and 24-hour recovery time revealed inflammation of the airways with varying degrees of injury from loss of cilia, degeneration of epithelium, and squamous metaplasia to submucosal edema. These histological changes were reflected in variable expression of the secretory Muc5AC and low expression of membrane-associated Muc4 mucin genes. Twenty-minute smoke exposure in extended recovery experiments showed marked disorder of tracheal epithelium for up to 72 hours of recovery with a return to normal by 7 days,"...


Source: Vaccine Weekly (2004-09-08)

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